Curcuma Longa (standardized 95 % Curcuminoids), has been reported to modulate growth factors, enzymes, transcription factors, kinase, inflammatory cytokines, and proapoptotic (by upregulation) and antiapoptotic (by downregulation) proteins.¹ This polyphenol compound, alone or combined with other agents, represents an effective supplement during cancer therapy. Laboratory and animal research suggests that curcumin may prevent cancer, slow the spread of cancer, make chemotherapy more effective and protect healthy cells from damage by radiation therapy. Turmeric and black pepper each have health benefits, due to the compounds curcumin and piperine. As piperine enhances curcumin absorption in the body by up to 2,000%, combining the spices magnifies their effects. They may reduce inflammation and improve digestion, particularly in supplement form. Piperine OF Pipper Nigram Extract seems to play a role in the death of certain cancer cells as well, which can decrease your risk of tumor formation, while other research indicates it, too, might inhibit the growth of cancerous cells ² Resveratrol, a natural stilbene and a non-flavonoid polyphenol, is a phytoestrogen that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. It has been reported that resveratrol can reverse multidrug resistance in cancer cells, and, when used in combination with clinically used drugs, it can sensitize cancer cells to standard chemotherapeutic agents.³ Cancer preventive activities of Green Tea Extract and its main constituent, (−)-epigallocatechin gallate (EGCG) have been extensively studied by scientists all over the world. EGCG inhibited self-renewal and expression of pluripotency-maintaining transcription factors in human cancer stem cells.⁴ The existence of cancer stem cells (CSCs) in breast cancer has profound implications for cancer prevention. Sulforaphane, a natural compound derived from broccoli /broccoli sprouts, has efficacy to inhibit breast CSCs. However further studies are going on.⁵ Asparagus comprises phytoestrogens which can be used for the treatment of breast cancer. A. could be used as a new source for the treatment of breast cancer.⁶ In the current study, In vitro antiproliferative activity of the extracts of A. racemosus is performed in T47D cancer cell lines. Outcomes of the result indicated that aqueous methanol and methanol extract showed excellent antiproliferative activity. One study on the effects of silibinin of Milk Thistle on MCF-7 breast cancer cells suggests the compound inhibits the cells' growth and induces their death. The study concluded that silibinin might be “an effective adjuvant drug to produce a better chemo preventive response for the cancer therapy.” A separate study on the effects of silibinin on MCF-7 human breast cancer cells also found it causes cell death and a loss of viability. Astaxanthin treatment is an effective method of reducing the proliferation and migration of breast cancer cells. Astaxanthin has shown demonstrated a consistent ability to reduce multiple types of cancer.⁷ Due to its anti-oxidant, anti-tumor and anti-inflammatory activity, quercetin has been studied extensively as a chemoprevention agent in several cancer models. Quercetin has been shown to inhibit the proliferation of a wide range of cancers such as prostate, cervical, lung, breast, and colon.⁸   Gamma-Linolenic acid (GLA), an essential omega-6 polyunsaturated fatty acid (FA) is an attractive concept as anticancer agent because it exerts selective cytotoxic on human breast cancer cells without affecting normal cells. Accumulating evidence suggests that Vitamin B3 plays a role in cancer prevention and therapy. Phase III clinical trials have confirmed its clinical efficacy for non-melanoma skin cancer chemoprevention or as an adjunct to radiotherapy against head and neck, laryngeal, and urinary bladder cancers. There are studies where patients were supplemented with a daily dose of CoQ10, resulted in increased antioxidant levels, decreased cytokines plasma levels and reduced cancer biomarkers. Most of the published literature suggests that plasma folate levels are inversely associated with the risk of breast cancer. So, supplying folic acid will aid the therapy. Research suggests that women with low levels of vitamin D have a higher risk of breast cancer. Vitamin D may play a role in controlling normal breast cell growth and may be able to stop breast cancer cells from growing. Small clinical trials of N- Acetyl Cysteine suggest potential to reduce cancer-treatment toxicities. References:

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